Asymmetric Catalysis

The group focus on the development of new catalytic asymmetric processes for the synthesis of chiral intermediates potentially useful for applications in pharmaceutical, agrochemical and perfumery industries. In the frame of this main objective, the group focus in the design of ‘tailor-made’ catalysts structures for relevant applications. Different aspects are covered within this broad context, including transition-metal mediated catalysis (specially by complexes based in N-heterocyclic carbene and hydrazone ligands) and Organocatalysis, with emphasis in the development of new activation strategies and environmentally bening processes using water water as the reaction medium. The specific  objectives targeted vary from the improvement of properties such as the catalytic activity and selectivity for known reactions to the development of new synthetic methodologies based in unprecedented reactivities.

7th Framework Program, Ministerio de Ciencia e Innovación and Junta de Andalucía
Selected Publications
Type: Publications in journals
Catalytic enantioselective synthesis of α-aryl α-hydrazino esters and amides
Authors: M. Velázquez, S. Alberca, J. Iglesias-Sigüenza, R. Fernández, J. M. Lassaletta and D. Monge
Publication Year: 2020
Pages: Advance Article, DOI 10.1039/D0CC02478C
Magazine: Chemical Communications
Type: Publications in journals
Ir-Catalyzed Atroposelective Desymmetrization of Heterobiaryls: Hydroarylation of Vinyl Ethers and Bicycloalkenes
Authors: A. Romero-Arenas, V. Hornillos, J. Iglesias-Sigüenza, R. Fernández, J. López-Serrano, A. Ros and J. M. Lassaletta
Publication Year: 2020
Pages: 2628-2639, DOI 10.1021/JACS.9B12858
Magazine: Journal of the American Chemical Society
Volume: 142 (5)
Patents
Procedimiento de obtención de un azocompuesto o nitrosoderivado enantioméricamente puro o enriquecido mediante reacción hetero-carbonil-énica
Inventors: Lassaleta SImón, José María; Crespo Peña, Ana; Monge Fernández, David; Fernández Fernández, Rosario; Martín Zamora, María Eloisa
Date: 23/05/2012
Derivado 2,6-diborilado de areno y su obtención mediante diborilación orto-dirigida
Inventors: José María Lassaleta Simón, Abel Ros Laó, Rocío López Rodríguez, Rosario Fernández Fernández, Beatriz Estepa Sánchez
Date: 21/02/2012