Asymmetric Synthesis and Functional Nanosystems Group

The research carried out in the AS@FUN group can be divided into three main axes: (i) Asymmetric Synthesis using Chiral Sulfur Derivatives, (ii) Asymmetric Catalysis using Carbohydrate ligands, (ii) Synthesis of Functional Nanosystems based on Carbon Nanotubes. All these subjects have in common the utilization of carbohydrates either as inexpensive chiral codifying agents or as molecular recognition elements of biological receptors implied in unsolved pathological processes.

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Ministerio de Ciencia e Innovación and Junta de Andalucía
Selected Publications
Type: Publications in journals
N-Isopropylsulfinylimines vs. N-tert-butylsulfinylimines in the stereoselective synthesis of sterically hindered amines: an improved synthesis of enantiopure (R)- and (S)-rimantadine and the trifluoromethylated analogues
Authors: N. Moreno, R. Recio, V. Valdivia, N. Khiar and I. Fernández
Publication Year: 2019
Pages: 9854-9858, DOI: 10.1039/c9ob02241d
Magazine: Organic & Biomolecular Chemistry
Volume: 17 (46)
Type: Publications in journals
Steric Tuning of Sulfinamide/Sulfoxides as Chiral Ligands with C1, Pseudo-meso, and Pseudo‑C2 Symmetries: Application in Rhodium(I)-Mediated Arylation
Authors: L. G. Borrego, R. Recio, E. Álvarez, A.Sánchez-Coronilla, N. Khiar and I. Fernández
Publication Year: 2019
Pages: 6513-6518, doi.org/10.1021/acs.orglett.9b02405
Magazine: Organic Letters
Volume: 21 (16)
Patents
Nanoparticles for diagnosis and drug delivery
Inventors: Khiar el Wahabí N.; Wellinger R. E.
Date: 09/12/2015
Antagonistas de los receptores NK1 derivados de hidratos de carbono, método de obtención y uso médico
Inventors: Khiar el Wahabí N.; Fernández Fernández I. Recío Jiménez R.
Date: 23/04/2015
Compuestos Derivados de Sulforafano, método de Obtención y su Uso Médico, Alimenticio y Cosmético
Inventors: Khiar el Wahabi N.; Fernández Fernández I; Rocio Recio
Date: 06/03/2013
Neoglicolípidos, sus agregados con nanotubos de carbono, procedimiento de obtención y aplicaciones
Inventors: Fernández Fernández, Inmaculada; Khiar El Wahabi, Noureddine; Pernía Leal, Manuel
Date: 22/09/2010
Fosfinitos tioglicósidos. Procedimiento de preparación y utilización como nuevos ligandos en catálisis asimétrica.
Inventors: Fernández Fernández, Inmaculada; Khiar El Wahabi, Noureddine; Suárez Jiménez, María Belén
Date: 15/04/2008
Procedimiento para la preparación de fosfinas y óxidos de fosfinas quirales a partir de di-O-alquiliden y di-O-ariliden-D-glucofuranosilo
Inventors: Alcudia Cruz, A.; Benabra, A.; Khiar el Wahabi, N.; Fernández Fernández, I.; Alcudia González, F.
Date: 01/03/2000
Carbohydrates and Methods for their Synthesis
Inventors: Martín-Lomas, M.; M. Flores Mosquera, M.; Khiar el Wahabi, N.
Date: 27/11/1998