Biointeractomics

 

The research work of the group is mainly aimed at analysing the structure and function of biological macromolecules, as well as studying transient protein-protein and protein-nucleic acid interactions – which are crucial for a broad range of cell processes.  In the lab we also focus on gaining a deeper insight into the post-translational modifications of proteins, and in particular, of mitochondrial cytochrome c (Cc) – a protein which plays a double role in redox metabolism and programmed cell death (PCD), upon chemical modification by nitration and phosphorylation. In addition, we attempt to provide further understanding of the evolution of cell death by performing proteomic analysis aimed at identifying novel targets of Cc in humans, plants and green algae.

Our research work is clear-cut multi- and interdisciplinary in nature. In collaboration with other laboratories worldwide, we usually apply a broad diversity of methodologies and techniques ranging from molecular and cell biology to biochemistry, biophysics, structural biology and computational chemistry.

- Structure-Function Relationships of Proteins

- Transient Interactions between Biological Macromolecules

- Cytochrome c and Evolution of Programme Cell Death

Ministry of Science, Innovation and Universities, Andalusian Government, Ramón Areces Foundation

 

Available Positions

We are always interested in talented students and researchers that wish to join our group. Motivated candidates should send us their CV by e-mail.

Selected Publications

Type: Publications in journals
Inhibition of the PP2A activity by the histone chaperone ANP32B is long-range allosterically regulated by respiratory cytochrome c
Authors: Rivero-Rodríguez, F., Díaz-Quintana, A., Velázquez-Cruz, A., González-Arzola, K., Gavilan, M.P., Velázquez-Campoy, A., Ríos, R.M., De la Rosa, M.A., Díaz-Moreno, I.
Publication Year: 2021
Pages: 101967
DOI: 10.1016/j.redox.2021.101967
Magazine: Redox Biology
Type: Publications in journals
Exploring Protein Phosphorylation by Combining Computational Approaches and Biochemical Methods
Authors: Pérez-Mejías, G., Velázquez-Cruz, A., Guerra-Castellano, A., Baños-Jaime, B., Díaz-Quintana, A., González-Arzola, K., De la Rosa, M.A. and Díaz-Moreno, I.
Publication Year: 2020
Pages: 1852-1863
DOI: 10.1016/j.csbj.2020.06.043
Magazine: Computational and Structural Biotechnology Journal
Type: Publications in journals
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
Authors: Pabis M, Popowicz GM, Stehle R, Fernández-Ramos D, Asami S, Warner L, García-Mauriño SM, Schlundt A, Martínez-Chantar ML, Díaz-Moreno I, Sattler M.
Publication Year: 2019
Pages: 1011–1029
DOI: 10.1093/nar/gky1138
Magazine: Nucleic Acids Research