Biointeractomics

 

The research work of the group is mainly aimed at analysing the structure and function of biological macromolecules, as well as studying transient protein-protein and protein-nucleic acid interactions – which are crucial for a broad range of cell processes.  In the lab we also focus on gaining a deeper insight into the post-translational modifications of proteins, and in particular, of mitochondrial cytochrome c (Cc) – a protein which plays a double role in redox metabolism and programmed cell death (PCD), upon chemical modification by nitration and phosphorylation. In addition, we attempt to provide further understanding of the evolution of cell death by performing proteomic analysis aimed at identifying novel targets of Cc in humans, plants and green algae.

Our research work is clear-cut multi- and interdisciplinary in nature. In collaboration with other laboratories worldwide, we usually apply a broad diversity of methodologies and techniques ranging from molecular and cell biology to biochemistry, biophysics, structural biology and computational chemistry.

- Structure-Function Relationships of Proteins

- Transient Interactions between Biological Macromolecules

- Cytochrome c and Evolution of Programme Cell Death

Ministry of Economy and Competitiveness, Andalusian Government, Ramón Areces Foundation

 

Available Positions

We are always interested in talented students and researchers that wish to join our group. Motivated candidates should send us their CV by e-mail.

Selected Publications
Type: Publications in journals
Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria
Authors: Alejandra Guerra-Castellano, Antonio Díaz-Quintana, Gonzalo Pérez-Mejías, Carlos A. Elena-Real, Katiuska González-Arzola, Sofía M. García-Mauriño, Miguel A. De la Rosa, and Irene Díaz-Moreno
Publication Year: 2018
Pages: https://doi.org/10.1073/pnas.1806833115
Magazine: Proc. Natl. Acad. Sci. U.S.A.
Type: Publications in journals
Structural Basis of Mitochondrial Dysfunction in Response to Cytochrome c Phosphorylation at position 48
Authors: Blas Moreno-Beltrán, Alejandra Guerra-Castellano, Antonio Díaz-Quintana, Rebecca Del Conte, Sofía García-Mauriño, Sofía Díaz-Moreno, Katiuska González-Arzola, Carlos Santos-Ocaña, Adrian Velazquez-Campoy, Miguel De la Rosa, Paola Turano, Irene Diaz-Moreno
Publication Year: 2017
Pages: doi: 10.1073/pnas.1618008114
Magazine: Proc. Natl. Acad. Sci. U.S.A.

Publications in books
Redox Proteins in Supercomplexes and Signalosomes
Editors: Louro, R., Díaz-Moreno, I.
2015
CRC Press
978-1-4822-5110-4
International
 

FEBS 2018 Advanced Course: Integrated Approaches to Biomolecular Interactions

7-11 Mayo de 2018, Sevilla, España. https://biomolecularinteractions.febsevents.org