Francisco Javier Rojo Marcos

Professional: 
Senior researcher
Email: 
javier [dot] rojo [at] iiq [dot] csic [dot] es
Phone Extension: 
909609
Otra informaciĆ³n: 

 

Group web

 

Biography

Javier Rojo received a BSc in Chemistry in 1989 at the University Autónoma Madrid (UAM) and his PhD degree in Chemistry in 1995 also at UAM under the supervision of Prof. Juan Carlos Carretero. He was a postdoctoral fellow with Prof. Jean-Marie Lehn at the University Louis Pasteur in Strasbourg (1995-1998) and with Prof. Larry W. McLaughlin at Boston College in USA (1998-1999). In January 2000, he joined the group of Carbohydrates at the Spanish Research Council (CSIC) in Seville as an associate researcher. In 2001 was awarded with a Ramón y Cajal grant and in 2004 he became CSIC permanent research scientist.

Research Areas

Research topics are focused on the development of glycodendritic structures and the study of their biological applications. Specifically, this research is centred on the design, synthesis and characterization of multivalent systems based on dendrimers and dendrons adequately functionalized to conjugate carbohydrates and other molecules of biological interest such as peptides, nucleic acids, etc. These systems are design to study the interaction with the lectin DC-SIGN present at the surface of dendritic cells. The principal aim is the development of antiviral compounds and molecules acting as modulators of the immune response mediated by that lectin.

Publicaciones notables

1. A. Muñoz, B.M. Illescas, M. Sánchez-Navarro, J. Rojo, N. Martín. Nanorods versus nanovesicles from amphiphilic dendrofullerenes.  J. Am. Chem. Soc.  in press.

   

2.M. Sánchez-Navarro, A. Muñoz, B.M. Illescas, J. Rojo, N. Martín. [60]Fullerene as multivalent scaffold: efficient molecular recognition of globular glycofullerenes by Con A.Chem. Eur. J., 17, 766-769, (2011).

 

3. J. Luczkowiak, S. Sattin, I. Sitkeviciute, J.J. Reina, M. Sánchez-Navarro, M. Thépaut, L. Martínez-Orats, A, Daghetti, F. Fieschi, R. Delgado, A. Bernardi, J. Rojo. Pseudosaccharide functionalized dendrimers as potent inhibitors of DC-SIGN dependent Ebola pseudotyped viral infection.Bioconjugate Chem.  22, 1354–1365, (2011)

 

4. S Sattin, A. Daghetti, M Thépaut, A. Berzi, M. Sánchez-Navarro, G. Tabarani, J. Rojo, F. Fieschi, M. Clerici, A. Bernardi, Inhibition of DC-SIGN-mediated HIV infection by a linear trimannoside mimic in a tetravalent presentation. ACS Chem. Biol., 3, 301-312, (2010)

 

5. J.J. Reina, I. Díaz, P.M. Nieto, N.E. Campillo, J.A. Páez, G. Tabarani, F. Fieschi, J. Rojo.
Docking, Synthesis and NMR Studies of Mannosyl Trisaccharide Ligands for DC-SIGN Lectin.
Org. Biomol. Chem., 6, 2743-2754, (2008)