Glycosystems Laboratory

The main goal of the Glycosystems Laboratory is the study in detail of the biologically relevant recognition processes involving carbohydrates, with the aim to intervene on them. In particular, through different funded research projects, this laboratory is focused on the synthesis of carbohydrates, glycoconjugates, and carbohydrate multivalent systems, the study of these entities at the structural level using computational and Nuclear Magnetic Resonance (NMR) techniques, and the analysis of the interactions of these carbohydrate systems with their corresponding receptors using different approaches. The final goal of these studies is the understanding of these processes and the development of useful tools to be applied on glycobiology and biomedicine.

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7th Framework Program, Ministerio de Ciencia e Innovación, Consejo Superior de Investigaciones Científicas and Junta de Andalucía
Selected Publications
Type: Publications in journals
Langerin–Heparin Interaction: Two Binding Sites for Small and Large Ligands As Revealed by a Combination of NMR Spectroscopy and Cross-Linking Mapping Experiments.
Authors: Muñoz-García, J. C.; Chabrol, E.; Vivès, R. R.; Thomas, A.; de Paz, J. L.; Rojo, J.; Imberty, A.; Fieschi, F.; Nieto, P. M.; Angulo, J.
Publication Year: 2016
Pages: 4100-4110
Magazine: J. Am. Chem. Soc.
Volume: 137 (12)
Type: Publications in journals
. Improvement on binding of chondroitin sulfate derivatives to midkine by increasing hydrophobicity
Authors: de Paz, J. L.; Nieto, P. M.
Publication Year: 2016
Pages: 3506-3509
Magazine: Org. Biomol. Chem.
Volume: 14 (14)
Patents
Derivados de galatos de alquilo como antioxidantes y surfactantes
Inventors: Juan C. Morales Sánchez, Ricardo Lucas Rodríguez, Olivia Sánchez Maldonado, Isabel Medina Méndez, Francesc Comelles Folch, José L. Parra Juez
Date: 14/06/2011
Derivados fenólicos lipófilos como surfactantes
Inventors: Juan Carlos Morales Sánchez, Francisco Comelles Folch, José Luis Parra Juez
Date: 21/12/2009
Compounds with anti-inflammatory activity
Inventors: Juan Carlos Espín de Gea, Juan Carlos Morales Sánchez, Mª Isabel Medina Méndez
Date: 15/09/2009
Inhibitors of Microbial Infections
Inventors: A. Bernardi, S. Sattin, M. Clerici, A: Berzi, F.J. Rojo, M. Sánchez, J.J Reina, F. Fieschi
Date: 03/07/2009
Nanoparticles
Inventors: Soledad Penadés, Javier Rojo , Manuel Martín Lomas.
Date: 16/10/2000