Pedro Manuel Nieto Mesa

Categoría Profesional: 
Investigador Científico
Correo electrónico: 
pedro [dot] nieto [at] iiq [dot] csic [dot] es
Extensión Teléfonica: 
95 448 9568
Otra información: 

 

Biography

Pedro M. Nieto obtained his PhD in the Universidad Autónoma de Madrid in 1994 under the supervisión of Prof. Javier de Mendoza and Dr. Pilar Prados in Supramolecular Chemistry of Calix[6]arenes with honors. After he did postdoctoral work in the National Institute for Medical Research from the Medical Research Council with Dr. Jim Feeney in the Dept. of Molecular Structure working in Protein NMR interested in the dynamic aspects and in the relationship between structure and dynamics. In 1997 moved to the Instituto de Investigaciones Químicas in Sevilla joining the “Grupo de Carbohidratos” with Prof. Manuel Martín-Lomas where become responsible of the structural projects. In 2001 awarded a Ramón y Cajal Fellowship and became CSIC tenured Scientist in 2002. Since then, has been working in different aspects of the Molecular Recognition of Biomolecules always from a structural perspective and combining experimental NMR data with theoretical calculations. During this period has been taking duties as responsible of the NMR facilities of the IIQ. In 2010 promotes to CSIC Researcher.

Research Areas

  • Molecular basis of the molecular recognition of carbohydrates by proteins using NMR and Computational Tools (MD, MD-tar and Docking)
    • Glycosaminoglycans and Protein (FGF-1, ECP) Interactions
    • DC-SIGN / Langerin and carbohydrates or glycomimetics
  • Three-dimensional structure of carbohydrates of biological relevance
    • GPI
    • Iminosugars
  • NMR methodological aspects on redox proteins.
  • New NMR sequences and tools for structural elucidation.

Publications

1. M. Thepaut, C. Guzzi, I. Sutkeviciute, S. Sattin, R. Ribeiro-Viana, N. Varga, E. Chabrol, J. Rojo, A. Bernardi, J. Angulo, P. M. Nieto, F. Fieschi. Structure of a Glycomimetic Ligand in the Carbohydrate Recognition Domain of C-type Lectin DC-SIGN. Structural Requirements for Selectivity and Ligand Design. J. Am. Chem. Soc. 2013, 135 (7), 2518-29.

 

2. M. F. García-Mayoral, Á. Canales, D. Díaz, J. López-Prados, M. Moussaoui, J. L. de Paz, J. Angulo, P. M. Nieto, J. Jiménez-Barbero, E. Boix, M. Bruix. Insights into the Glycosaminoglycan-Mediated Cytotoxic Mechanism of Eosinophil Cationic Protein Revealed by NMR. ACS Chem. Biol. 2013, 8 (1), 144-51.

 

3. J. C. Munoz-Garcia, J. Lopez-Prados, J. Angulo, I. Diaz-Contreras, N. Reichardt, J. L. de Paz, M. Martin-Lomas, P. M. Nieto. Effect of the Substituents of the Neighboring Ring in the Conformational Equilibrium of Iduronate in Heparin-like Trisaccharides. Chem. Eur. J. 2012, 18 (51), 16319-31.

 

4. C. Guzzi, J. Angulo, F. Doro, J. J. Reina, M. Thepaut, F. Fieschi, A. Bernardi, J. Rojo, P. M. Nieto.Insights into molecular recognition of Lewis(X) mimics by DC-SIGN using NMR and molecular modelling. Org. Biomol. Chem. 2011, 9 (22), 7705-12.

 

5. J. Angulo, P. M. Enriquez-Navas, P. M. Nieto. Ligand-Receptor Binding Affinities from Saturation Transfer Difference (STD) NMR Spectroscopy: The Binding Isotherm of STD Initial Growth Rates. Chem. Eur. J. 2010, 16 (26), 7803-12.

 

6. J. Angulo, I. Diaz, J. J. Reina, G. Tabarani, F. Fieschi, J. Rojo, P. M. Nieto. Saturation Transfer Difference (STD) NMR Spectroscopy Characterization of Dual Binding Mode of a Mannose Disaccharide to DC-SIGN. ChemBioChem 2008, 9 (14), 2225-7.